Intestinal lymphatic absorption of cyclosporin A following oral administration in an olive oil solution in rats.
作者： Clarence T. Ueda , Michel Lemaire , Guy Gsell , Kurt Nussbaumer
关键词: Cyclosporin a 、 Oral administration 、 Intestinal absorption 、 Drug 、 Lymphatic system 、 Absorption (pharmacology) 、 Lymph 、 Bioavailability 、 Pharmacology 、 Chemistry
摘要: The intestinal lymphatic absorption of cyclosporin A (CyA) following oral administration 6.5 +/- 0.6 and 25.2 1.4 mg kg-1 doses the drug dissolved in an olive oil solution was studied using a thoracic duct-cannulated rat model. Cumulative lymph samples were collected for up to 114 h post-dosing assayed by liquid scintillation counting. In this study, estimated amount lymphatically absorbed CyA 0.35 0.13 0.47 0.29 per cent respective doses. terms overall bioavailability (Fpo) all absorptive mechanisms, lymphatics accounted approximately 2 total drug. Fpo 21.3 2.5 cent. results study suggested that lipophilicity alone not only factor governing absorption. An explanation low level is presented. addition, some reasons are discussed.
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