Analysis of relationships between the concentrations of total testosterone and dehydroepiandrosterone sulfate and the occurrence of selected metabolic disorders in aging men

作者: Iwona Rotter , Danuta Kosik-Bogacka , Barbara Dołęgowska , Karolina Skonieczna-Żydecka , Wioletta Pawlukowska

DOI: 10.3109/13685538.2015.1077507

关键词: EndocrinologyInternal medicineLipoproteinOverweightTriglycerideMedicineBody mass indexTestosteroneDehydroepiandrosterone sulfateMetabolic syndromeDehydroepiandrosterone

摘要: AbstractObjective: The evaluation of relationships between the concentrations dehydroepiandrosterone sulfate (DHEAS) and total testosterone (TT) occurrence metabolic disorders, including syndrome (MetS).Method: participants were subjected to anthropometric measurements tested for DHEAS, TT, lipid parameters carbohydrate parameters.Result: We observed a lower concentration DHEAS in men with hypertension (HT) compared those without HT. In MetS, HT, overweight obesity, TT was than these problems. found statistically significant positive correlations (DHEAS– cholesterol [TCh], DHEAS– low-density lipoprotein [LDL], TT– high-density [HDL], TT–waist-to-hip ratio [WHR]) negative (DHEAS–age, TT–body weight, body mass index [BMI], TT–abdominal circumference [AC], TT–hip [HC], triglyceride [TG], fasting plasma glucose [FPG], serum insuli...

参考文章(74)
Abdulmaged M. Traish, H. Paco Kang, Farid Saad, Andre T. Guay, Dehydroepiandrosterone (DHEA)—A Precursor Steroid or an Active Hormone in Human Physiology (CME) The Journal of Sexual Medicine. ,vol. 8, pp. 2960- 2982 ,(2011) , 10.1111/J.1743-6109.2011.02523.X
Farid Saad, Ahmad Haider, Gheorghe Doros, Abdulmaged Traish, Long‐term treatment of hypogonadal men with testosterone produces substantial and sustained weight loss Obesity. ,vol. 21, pp. 1975- 1981 ,(2013) , 10.1002/OBY.20407
Dominique Maiter, Jacques Jamart, René De Hertogh, Orsalia Alexopoulou, Michel Hermans, Martin Buysschaert, Philippe De Nayer, Erectile dysfunction and lower androgenicity in type 1 diabetic patients. Diabetes & Metabolism. ,vol. 27, pp. 329- 336 ,(2001)
G Corona, Edoardo Mannucci, L Petrone, Valdo Ricca, Giancarlo Balercia, R Mansani, V Chiarini, R Giommi, Gianni Forti, Mario Maggi, None, Association of hypogonadism and type II diabetes in men attending an outpatient erectile dysfunction clinic International Journal of Impotence Research. ,vol. 18, pp. 190- 197 ,(2006) , 10.1038/SJ.IJIR.3901391
Toshiyuki Yasui, Hirokazu Uemura, Minoru Irahara, Makoto Arai, Noriko Kojimahara, Ryugo Okabe, Yasutomo Ishii, Shin-ichi Tashiro, Hiroshi Sato, Associations of endogenous sex hormones and sex hormone-binding globulin with lipid profiles in aged Japanese men and women Clinica Chimica Acta. ,vol. 398, pp. 43- 47 ,(2008) , 10.1016/J.CCA.2008.08.006
Chaoyang Li, Earl S Ford, Benyi Li, Wayne H Giles, Simin Liu, Association of testosterone and sex hormone-binding globulin with metabolic syndrome and insulin resistance in men. Diabetes Care. ,vol. 33, pp. 1618- 1624 ,(2010) , 10.2337/DC09-1788
Y. Umeda-Kameyama, M. Akishita, S. Fukai, M. Hashimoto, K. Nomura, T. Nakamura, S. Ogawa, K. Iijima, M. Eto, Y. Ouchi, Association of low testosterone with metabolic syndrome and its components in middle-aged Japanese men Journal of Men's Health. ,vol. 7, pp. 309- 309 ,(2010) , 10.1016/J.JOMH.2010.09.089
Giorgio Valenti, None, Consensus Document on substitution therapy with DHEA in the elderly Aging Clinical and Experimental Research. ,vol. 18, pp. 277- 300 ,(2006) , 10.1007/BF03324662
C. Berr, S. Lafont, B. Debuire, J.-F. Dartigues, E.-E. Baulieu, Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: A French community-based study Proceedings of the National Academy of Sciences of the United States of America. ,vol. 93, pp. 13410- 13415 ,(1996) , 10.1073/PNAS.93.23.13410
Abdelouahid Tajar, Ilpo T. Huhtaniemi, Terence W. O'Neill, Joseph D. Finn, Stephen R. Pye, David M. Lee, György Bartfai, Steven Boonen, Felipe F. F. Casanueva, Gianni Forti, Aleksander Giwercman, Thang S. Han, Krzysztof Kula, Fernand Labrie, Michael E. J. Lean, Neil Pendleton, Margus Punab, Dirk Vanderschueren, Frederick C. W. Wu, , Characteristics of Androgen Deficiency in Late-Onset Hypogonadism: Results from the European Male Aging Study (EMAS) The Journal of Clinical Endocrinology and Metabolism. ,vol. 97, pp. 1508- 1516 ,(2012) , 10.1210/JC.2011-2513