Evaluation of acute and subacute toxicity of hydroethanolic extract of Dolichandra unguis-cati L. leaves in rats

摘要: Abstract Ethnopharmacological relevance Dolichandra unguis-cati L. is a native climbing plant of Brazil, popularly known as “unha de gato”. It has been traditionally used mainly an antipyretic, anti-inflammatory and anti-tumor agent, yet little toxicological information found in the literature. Aim study To identify chemical composition hydroethanolic extract obtained from leaves uniguis-cati to evaluate acute subacute toxicity male female rats, order assess safety profile this plant. Materials methods In study, single dose (2000 mg/kg) was orally administered rats. rats at doses 100, 200 400 mg/kg for 28 days. Behavioral changes, catalase tbars evaluations, biochemical, hematological histopathological analysis were determined. The extract’ accessed through UHPLC/MS. Results Chlorogenic acid, caffeic ferulic vanillinic p-coumaric rosmarinic trans -cinnamic luteolin, apigenin, quercitrin quercetin identified extract. treatment, classified safe (category 5), according OECD guide. relation females showed reduction AST (100, 400 mg/kg), ALT (200 mg/kg) BUN (100 200 mg/kg) levels, while presented increase levels. Chol dosage significantly decreased dose-dependent manner, whereas parameter no statistically significant reductions. No behavioral changes recorded. Conclusions Our results indicate that did not present relevant toxic effects when also potential hypocholesterolemic activity.