Vitamin D receptor polymorphism and colorectal cancer-specific and all-cause mortality.

作者: Laura Perna , Michael Hoffmeister , Ben Schöttker , Volker Arndt , Ulrike Haug

DOI: 10.1016/J.CANEP.2013.09.007

关键词: Hazard ratioMedicineInternal medicineColorectal cancerFokITaqICalcitriol receptorVitamin D and neurologyImmunologyPopulationClinical significanceOncology

摘要: Abstract Background The vitamin D receptor ( VDR ) gene is present in colorectal cancer (CRC) cells and its genetic variants have been associated with an increased risk of CRC. association prognosis remains widely unexplored. Methods 1397 patients participating two cohorts (ESTHER II VERDI) a population-based case–control study (DACHS) were followed for 5 years. Unadjusted adjusted hazard ratios all-cause mortality (469 events) CRC-specific (336 estimated rs731236 (TaqI), rs2228570 (FokI), rs11568820 (Cdx2), rs1989969 (VDR-5132). Results No was found between polymorphism CRC specific mortality. Adjusted ranged from 0.79 (95% CI 0.57–1.12) to 1.14 0.89–1.46) 0.89 0.67–1.18) 1.22 0.99–1.50) All 95% confidence intervals included the null value. Conclusions Our findings do not support hypothesis that common investigated this are clinical relevance respect prognosis.

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