Optimization of 5-flurouracil solid-lipid nanoparticles: a preliminary study to treat colon cancer.

摘要: Solid lipid nanoparticle (SLNs) formulae were utilized for the release of 5-flurouracil (5-FU) inside colonic medium local treatment colon cancer. SLNs prepared by double emulsion-solvent evaporation technique (w/o/w) using triglyceride esters, Dynasan™ 114 or 118 along with soyalecithin as parts. Different formulation parameters; including type Dynasan, soyalicithin:Dynasan ratio, drug:total and polyvinyl alcohol (PVA) concentration studied respect to particle size drug entrapment efficiency. Results showed that formula 8 (F8) composition 20% 5-FU, 27% 114, 53% soyalithicin andformula 14 (20% 118, soyalithicin), which stabilized 0.5% PVA, well F10 similar F8 but 2% PVA considered optimum they combined small relatively high encapsulation efficiencies. had a 402.5 nm ± 34.5 polydispersity value 0.005 an efficiency 51%, 617.3 54.3 49.1% efficiency, whereas F14 343 29 polydispersity, 59.09%. DSC FTIR results suggested existence lipids in solid crystalline state. Incomplete biphasic prolonged profile from both was observed phosphate buffer pH 6.8 simulated containing rat caecal contents. A burst magnitudes 26% 28.8% cumulative released noticed first hour samples incubated F14, respectively, followed slow reaching 50% 52% after 48 hours.