Highly Condensed Boron Cage Cluster Anions in 2D Carrier and Its Enhanced Antitumor Efficiency for Boron Neutron Capture Therapy
作者： Goeun Choi , Ie-Rang Jeon , Huiyan Piao , Jin-Ho Choy
关键词: Neutron capture 、 Biodistribution 、 Radiochemistry 、 Hydroxide 、 Permeation 、 Irradiation 、 Boron 、 Nanoparticle 、 Chemistry 、 Nuclear chemistry 、 Orders of magnitude (mass)
摘要: An attempt is made to apply layered double hydroxide (LDH) as a boron delivery carrier for neutron capture therapy (BNCT), which needs sufficient amount of in tumor cells its successful administration. To meet this requirement, nanohybrid (BSH-LDH), mercaptoundecahydro-closo-dodecaborate (BSH) anionic molecules LDH, developed system. The cellular content upon permeation BSH-LDH nanoparticles (42.4 µg 10B 10−6 cells) U87 glioblastoma cell line found be ≈2000 times larger than the minimum requirement (≈0.02 BNCT and also orders magnitude higher previous results (0.2–1.5 by those applied with other targeting strategies, eventually excellent efficiency even under such low dose (30 mL−1) weak irradiation (1 × 1012 n cm−2 corresponding 20 min) condition. According biodistribution studies xenograft mice model, tumor-to-blood ratio BSH BSH-LDH-treated-group 4.4-fold that intact treated one 2 h after drug treatment. present combined system provides promising integrative therapeutic platform cancer
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