Pharmacokinetics of Na2B12H11SH (BSH) in patients with malignant brain tumours as prerequisite for a phase I clinical trial of boron neutron capture
作者： D. Gabel , D. Preusse , D. Haritz , F. Grochulla , K. Haselsberger
DOI: 10.1007/BF01411994
关键词:
摘要: The disposition of Na2B12H11SH (BSH) in patients with malignant glioma has been investigated, preparation for a Phase I clinical trial boron neutron capture therapy. BSH was found to possess linear over the dosage interval investigated (up 75 mg/kg). A bi-phasic blood pharmacokinetics observed. Tumour-to-blood ratios showed variations between 0.08 and 5.1. data allow definition amount timing infusion protocol.
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