Gene regulation by non-coding RNAs.
作者： Veena S. Patil , Rui Zhou , Tariq M. Rana
DOI: 10.3109/10409238.2013.844092
关键词: Gene silencing 、 Genetics 、 Long non-coding RNA 、 RNA silencing 、 RNA 、 Small nucleolar RNA 、 microRNA 、 Argonaute 、 Computational biology 、 Non-coding RNA 、 Biology
摘要: The past two decades have seen an explosion in research on non-coding RNAs and their physiological pathological functions. Several classes of small (20-30 nucleotides) long (>200 been firmly established as key regulators gene expression myriad processes ranging from embryonic development to innate immunity. In this review, we focus our current understanding the molecular mechanisms underlying biogenesis function interfering (siRNAs), microRNAs (miRNAs) Piwi-interacting (piRNAs). addition, briefly review relevance human physiology pathology potential be exploited therapeutic agents.
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