Expression of the putative proto-oncogene His-1 in normal and neoplastic tissues.

摘要: The His-1 gene is expressed as a 3-kb spliced and polyadenylated RNA that believed to function in the absence of an encoded protein. precise unknown, but its transcriptional activation series mouse leukemias has implicated leukemogenesis when it abnormally expressed. To study oncogenic potential this more detail, we have examined normal tissue distribution during embryogenesis various adult tissues. expression was detected at low levels epithelia stomach, prostate, seminal vesicle, developing choroid plexus by situ hybridization. All other tissues lacked detectable hybridizing RNA, suggesting highly restricted these epithelial sites. These transcripts were not Northern blot analysis readily identified five carcinomas plexus. data indicate suggest inappropriate may contribute carcinogenesis.