High-dose carboplatin, thiotepa, and etoposide with autologous stem-cell rescue for patients with recurrent medulloblastoma. Children's Cancer Group.
作者： I J Dunkel , J M Boyett , A Yates , M Rosenblum , J H Garvin
DOI: 10.1200/JCO.1998.16.1.222
关键词: Autologous Stem Cell Rescue 、 Carboplatin 、 Medicine 、 Etoposide 、 Recurrent Medulloblastoma 、 Transplantation 、 Surgery 、 ThioTEPA 、 Chemotherapy 、 Hematopoietic stem cell transplantation
摘要: PURPOSEMedulloblastoma is a highly lethal disease when it recurs. Very few patients survive with conventional treatment. This study evaluated the use of high-dose carboplatin, thiotepa, and etoposide autologous stem-cell rescue (ASCR) in recurrent medulloblastoma.METHODSChemotherapy consisted carboplatin 500 mg/m2 (or area under curve = 7 mg/mL x min via Calvert formula) on days -8, -7, -6; thiotepa 300 250 -5, -4, -3; followed by ASCR day 0. In addition to study-prescribed therapy, 21 received other treatment: neurosurgical resection seven, chemotherapy 17, external-beam irradiation 11 cases.RESULTSTwenty-three medulloblastoma, aged two 44 years (median, 13 years) at ASCR, were treated. Three died treatment-related toxicities within ASCR; multiorgan system failure two, Aspergillus infection venoocclusive one. Seven 23...
sci-hub.se 参考文章(21)
Gregory H. Reaman, David G. Poplack, Lawrence J. Ettinger, Andrea Gillespie, Judy Sato, Diane E. Cole, Roger J. Packer, Lawrence J. Singher, Joseph Sam, Frank Balis, Richard L. Heideman, Phase I and pharmacokinetic evaluation of thiotepa in the cerebrospinal fluid and plasma of pediatric patients: evidence for dose-dependent plasma clearance of thiotepa. Cancer Research. ,vol. 49, pp. 736- 741 ,(1989)
M L Graham, J E Herndon, J R Casey, S Chaffee, G H Ciocci, J P Krischer, J Kurtzberg, M J Laughlin, D C Longee, J F Olson, N Paleologus, C N Pennington, H S Friedman, High-dose chemotherapy with autologous stem-cell rescue in patients with recurrent and high-risk pediatric brain tumors. Journal of Clinical Oncology. ,vol. 15, pp. 1814- 1823 ,(1997) , 10.1200/JCO.1997.15.5.1814
D R Newell, A D Pearson, K Balmanno, L Price, R A Wyllie, M Keir, A H Calvert, I J Lewis, C R Pinkerton, M C Stevens, Carboplatin pharmacokinetics in children: the development of a pediatric dosing formula. The United Kingdom Children's Cancer Study Group. Journal of Clinical Oncology. ,vol. 11, pp. 2314- 2323 ,(1993) , 10.1200/JCO.1993.11.12.2314
H S Friedman, J P Krischer, P Burger, W J Oakes, B Hockenberger, M D Weiner, J M Falletta, D Norris, A H Ragab, D H Mahoney, Treatment of children with progressive or recurrent brain tumors with carboplatin or iproplatin: a Pediatric Oncology Group randomized phase II study. Journal of Clinical Oncology. ,vol. 10, pp. 249- 256 ,(1992) , 10.1200/JCO.1992.10.2.249
J L Finlay, S Goldman, M C Wong, M Cairo, J Garvin, C August, B H Cohen, P Stanley, R A Zimmerman, B Bostrom, J R Geyer, R E Harris, J Sanders, A J Yates, J M Boyett, R J Packer, Pilot study of high-dose thiotepa and etoposide with autologous bone marrow rescue in children and young adults with recurrent CNS tumors. The Children's Cancer Group. Journal of Clinical Oncology. ,vol. 14, pp. 2495- 2503 ,(1996) , 10.1200/JCO.1996.14.9.2495
J J Jenkins, L E Kun, A Gajjar, R K Mulhern, R L Heideman, R A Sanford, E C Douglass, E H Kovnar, J A Langston, Medulloblastoma in very young children: outcome of definitive craniospinal irradiation following incomplete response to chemotherapy. Journal of Clinical Oncology. ,vol. 12, pp. 1212- 1216 ,(1994) , 10.1200/JCO.1994.12.6.1212
E. L. Kaplan, Paul Meier, Nonparametric Estimation from Incomplete Observations Springer Series in Statistics. ,vol. 53, pp. 319- 337 ,(1992) , 10.1007/978-1-4612-4380-9_25
Paul S. Gaynon, Lawrence J. Ettinger, Edward S. Baum, Stuart E. Siegel, Mark D. Krailo, G. Denman Hammond, Carboplatin in childhood brain tumors: A children's cancer study group phase II trial Cancer. ,vol. 66, pp. 2465- 2469 ,(1990) , 10.1002/1097-0142(19901215)66:12<2465::AID-CNCR2820661204>3.0.CO;2-N
Mark G. Belza, Sarah S. Donaldson, Gary K. Steinberg, Richard S. Cox, Philip H. Cogen, Medulloblastoma: freedom from relapse longer than 8 years--a therapeutic cure? Journal of Neurosurgery. ,vol. 75, pp. 575- 582 ,(1991) , 10.3171/JNS.1991.75.4.0575
Richard L. Heideman, Roger J. Packer, Gregory H. Reaman, Jeffrey C. Allen, Beverly Lange, Marc E. Horowitz, Seth M. Steinberg, Andrea Gillespie, Edward H. Kovnar, Frank M. Balis, David G. Poplack, A phase II evaluation of thiotepa in pediatric central nervous system malignancies Cancer. ,vol. 72, pp. 271- 275 ,(1993) , 10.1002/1097-0142(19930701)72:1<271::AID-CNCR2820720147>3.0.CO;2-K