Expressions of KAI1 and E-cadherin in nonsmall cell lung cancer and their correlation with vasculogenic mimicry

摘要: BACKGROUND Metastasis and recurrence are the most common reasons for treatment failure of nonsmall cell lung cancer (NSCLC). Vasculogenic mimicry (VM, new blood supply formation in malignant tumors), E-Cadherin (a calcium-dependent transmembrane glycoprotein that mediates intercellular adhesion), KAI1 suppressor gene tumor metastasis) all valuable factors metastasis prognosis diverse human cancers. However, correlation VM, E-Cadherin, NSCLC is still unclear. In this study, we analyzed correlations among these as well their respective with clinicopathological parameters survival NSCLC. METHODS The level 163 tissue samples was examined by immunhistochemistry. Clinical data were also collected. RESULTS Levels VM significantly higher, levels lower tissues than normal tissues. positively associated lymph node (LNM), size, grade, (TNM) stages, negatively patients' overall (OS). correlated LNM, TNM stage, OS. multivariate analysis, high KAI1, stages independently OS patients CONCLUSION expression may represent promising metastatic prognostic biomarkers, potential therapeutic targets