Evaluation of commercial von Willebrand factor collagen binding assays to assist the discrimination of types 1 and 2 von Willebrand disease
DOI: 10.1160/TH10-06-0360
关键词: Von Willebrand factor 、 Von Willebrand disease 、 Coagulopathy 、 Reference standards 、 Collagen metabolism 、 Antigen 、 Chemistry 、 Ristocetin Cofactor 、 Immunology
摘要: This study reports on the evaluation of seven commercial von Willebrand factor (VWF) collagen binding (VWF:CB) assays to potentially assist discrimination types 1 and 2 disease (VWD). Samples from 25 patients with type VWD, varying severity, were co-tested 16 samples 2A or 2B plus various control samples, using each VWF:CB assay assessed against our standard (reference) in-house assay, as well VWF antigen (VWF:Ag) ristocetin cofactor (VWF:RCo) assays. Commercial varied in their ability discriminate 2A/2B VWD. The optimal VWF:CB/VWF:Ag ratio at which occurred also differed between assays, some improvements observed (but not all) following a harmonisation process that aimed correct for different calibrator effects. Assay variability compromised utility test occasions. Future standardisation are needed before can be more fully globally utilised VWD diagnostic laboratories.
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