Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression
作者： Cristina López-Rodríguez , Christopher L Antos , John M Shelton , James A Richardson , Fangming Lin
关键词: Transcription factor 、 Aldose reductase 、 Gene expression 、 NFAT 、 Biology 、 Enhancer 、 Regulation of gene expression 、 NFAT5 、 Molecular biology 、 NFATC Transcription Factors
摘要: … , and the Na + /myo-inositol cotransporter. The aldose … transcriptional target of NFAT5. Our findings demonstrate a central role for NFAT5 as a tonicity-responsive transcription factor …
harvard.edu
core.ac.uk
elsevier.com
jstor.org 
sci-hub.se 参考文章(21)
Jason Trama, Qingjun Lu, Robert G Hawley, Steffan N Ho, None, The NFAT-related protein NFATL1 (TonEBP/NFAT5) is induced upon T cell activation in a calcineurin-dependent manner. Journal of Immunology. ,vol. 165, pp. 4884- 4894 ,(2000) , 10.4049/JIMMUNOL.165.9.4884
Gerald M. Rubin, Audrey M. Huang, A Misexpression Screen Identifies Genes That Can Modulate RAS1 Pathway Signaling in Drosophila melanogaster Genetics. ,vol. 156, pp. 1219- 1230 ,(2000) , 10.1093/GENETICS/156.3.1219
Cristina López-Rodrı́guez, José Aramburu, Lei Jin, Andrew S Rakeman, Mayako Michino, Anjana Rao, Bridging the NFAT and NF-κB Families Immunity. ,vol. 15, pp. 47- 58 ,(2001) , 10.1016/S1074-7613(01)00165-0
Baoxue Yang, Annemarie Gillespie, Elaine J. Carlson, Charles J. Epstein, A. S. Verkman, Neonatal mortality in an aquaporin-2 knock-in mouse model of recessive nephrogenic diabetes insipidus. Journal of Biological Chemistry. ,vol. 276, pp. 2775- 2779 ,(2001) , 10.1074/JBC.M008216200
Kaoru Aida, Yukinobu Ikegishi, Jing Chen, Masato Tawata, Sadahiro Ito, Shuichiro Maeda, Toshimasa Onaya, Disruption of aldose reductase gene (Akr1b1) causes defect in urinary concentrating ability and divalent cation homeostasis. Biochemical and Biophysical Research Communications. ,vol. 277, pp. 281- 286 ,(2000) , 10.1006/BBRC.2000.3648
H Moo Kwon, Joseph S Handler, None, Cell volume regulated transporters of compatible osmolytes. Current Opinion in Cell Biology. ,vol. 7, pp. 465- 471 ,(1995) , 10.1016/0955-0674(95)80002-6
Hiroshi Kitamura, Atsushi Yamauchi, Toshihiro Sugiura, Yasuko Matsuoka, Masaru Horio, Masaya Tohyama, Shoichi Shimada, Enyu Imai, Masatsugu Hori, Inhibition of myo-inositol transport causes acute renal failure with selective medullary injury in the rat Kidney International. ,vol. 53, pp. 146- 153 ,(1998) , 10.1046/J.1523-1755.1998.00747.X
H. Miyakawa, S. K. Woo, S. C. Dahl, J. S. Handler, H. M. Kwon, Tonicity-responsive enhancer binding protein, a Rel-like protein that stimulates transcription in response to hypertonicity Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 2538- 2542 ,(1999) , 10.1073/PNAS.96.5.2538
I. A. Graef, J. M. Gastier, U. Francke, G. R. Crabtree, Evolutionary relationships among Rel domains indicate functional diversification by recombination Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 5740- 5745 ,(2001) , 10.1073/PNAS.101602398
Patricia Fernández-Llama, Peter Andrews, Carolyn A. Ecelbarger, Søren Nielsen, Mark A. Knepper, Concentrating defect in experimental nephrotic syndrome: Altered expression of aquaporins and thick ascending limb Na+ transporters Kidney International. ,vol. 54, pp. 170- 179 ,(1998) , 10.1046/J.1523-1755.1998.00984.X