Cell volume regulated transporters of compatible osmolytes.
作者： H Moo Kwon , Joseph S Handler , None
DOI: 10.1016/0955-0674(95)80002-6
关键词:
摘要: Virtually all cells respond to hypertonicity by accumulating certain small organic solutes (compatible osmolytes) that, in contrast intracellular ions, do not perturb macromolecular function. Several important compatible osmolytes are accumulated coupled transport. Transcription of genes encoding these cotransporters is increased and a tonicity-responsive enhancer element has been identified. When return an iso-osmotic environment, rapidly lost through pathway that current evidence indicates may be volume-sensitive chloride channel.
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sci-hub.se 参考文章(47)
P. R. Cammarata, N. Agarwal, R. Reeves, Cheng Zhou, Hai-Qing Chen, Osmoregulatory alterations in myo-inositol uptake by bovine lens epithelial cells. Part 4: Induction pattern of Na(+)-myo-inositol cotransporter mRNA under hypertonic conditions denoting an early-onset, interactive, protective mechanism against water stress. Investigative Ophthalmology & Visual Science. ,vol. 35, pp. 4118- 4125 ,(1994)
A. Paredes, M. McManus, H. M. Kwon, K. Strange, Osmoregulation of Na(+)-inositol cotransporter activity and mRNA levels in brain glial cells. American Journal of Physiology-cell Physiology. ,vol. 263, ,(1992) , 10.1152/AJPCELL.1992.263.6.C1282
K. R. Hallows, C. H. Packman, P. A. Knauf, Acute cell volume changes in anisotonic media affect F-actin content of HL-60 cells American Journal of Physiology-cell Physiology. ,vol. 261, pp. 1- 1 ,(1991) , 10.1152/AJPCELL.1991.261.6.C1154
K. Strange, R. Morrison, L. Shrode, R. Putnam, Mechanism and Regulation of Swelling-Activated Inositol Efflux in Brain Glial Cells American Journal of Physiology-cell Physiology. ,vol. 265, ,(1993) , 10.1152/AJPCELL.1993.265.1.C244
A Yamauchi, S Uchida, H M Kwon, A S Preston, R B Robey, A Garcia-Perez, M B Burg, J S Handler, Cloning of a Na(+)- and Cl(-)-dependent betaine transporter that is regulated by hypertonicity. Journal of Biological Chemistry. ,vol. 267, pp. 649- 652 ,(1992) , 10.1016/S0021-9258(18)48543-2
H.F. Cantiello, A.G. Prat, J.V. Bonventre, C.C. Cunningham, J.H. Hartwig, D.A. Ausiello, Actin-binding protein contributes to cell volume regulatory ion channel activation in melanoma cells. Journal of Biological Chemistry. ,vol. 268, pp. 4596- 4599 ,(1993) , 10.1016/S0021-9258(18)53437-2
The tonicity-sensitive element that mediates increased transcription of the betaine transporter gene in response to hypertonic stress. Journal of Biological Chemistry. ,vol. 269, pp. 29379- 29381 ,(1994) , 10.1016/S0021-9258(18)43888-4
E.M. Schwiebert, J.W. Mills, B.A. Stanton, Actin-based cytoskeleton regulates a chloride channel and cell volume in a renal cortical collecting duct cell line. Journal of Biological Chemistry. ,vol. 269, pp. 7081- 7089 ,(1994) , 10.1016/S0021-9258(17)37249-6
Y Terada, K Tomita, M K Homma, H Nonoguchi, T Yang, T Yamada, Y Yuasa, E G Krebs, S Sasaki, F Marumo, Sequential activation of Raf-1 kinase, mitogen-activated protein (MAP) kinase kinase, MAP kinase, and S6 kinase by hyperosmolality in renal cells. Journal of Biological Chemistry. ,vol. 269, pp. 31296- 31301 ,(1994) , 10.1016/S0021-9258(18)47422-4
K Kirk, J.C. Ellory, J.D. Young, Transport of organic substrates via a volume-activated channel. Journal of Biological Chemistry. ,vol. 267, pp. 23475- 23478 ,(1992) , 10.1016/S0021-9258(18)35862-9