Left Atrial Morphology, Size and Function in Patients With Transthyretin Cardiac Amyloidosis and Primary Hypertrophic Cardiomyopathy - Comparative Strain Imaging Study.

摘要: BACKGROUND We sought to assess left atrial (LA) morphology and function in patients with transthyretin cardiac amyloidosis (TTR-CA) hypertrophic cardiomyopathy (HCM). Primarily, longitudinal deformation (reservoir) pump were the focus of vector-velocity strain echocardiography imaging. METHODS AND RESULTS The study group comprised 32 (mean age 57.7±15.4 years, 16 each group), 15 healthy controls. Diagnosis TTR-CA was based on either gadolinium-enhanced (LGE) magnetic resonance (cMRI) or radionuclide At baseline, there no differences age, body surface area, blood pressure risk factors among groups. Left ventricular (LV) mass greater than controls, slight LA dilatation found group. reservoir 14.1±4.7% TTR-CA, 20.0±5.6% HCM, 34.0±11.8% controls (<0.001). In addition, chiefly impaired former group, irrespective chamber size LV ejection fraction. LGE wall seen 9/10 versus 0/8 HCM undergoing cMRI (P<0.001). ≤19% ≤-1.1% best discriminated from receiver-operating characteristic analysis. CONCLUSIONS significantly both compared but mainly volume fraction, likely caused by a more altered structure. (Circ J 2016; 80: 1830-1837).