Bactericidal activity against coagulase-negative staphylococci is impaired in infants receiving long-term parenteral nutrition.

摘要: Total parenteral nutrition (TPN) has contributed to the recent improvement in care of newborn infants. However, this form nutritional support is associated with complications, particularly infection. Five percent 37% infants receiving TPN become bacteremic, 1–3 most frequently coagulase-negative staphylococci. 4 Infection may result impairment liver function or systemic inflammatory response syndrome, necessitating removal central venous catheters. It therefore represents a major clinical problem infancy. It generally believed that infection staphylococci results from contamination indwelling catheters by bacteria skin flora during handling intravenous also been suggested itself impair host defense mechanisms and contribute occurrence In preliminary studies, predominantly adults, lipid component shown affect several immunologic parameters, including cytokine production, 5,6 bactericidal activity, 7 neutrophil function. 8 To date, data on human are limited. In study, we demonstrate long-term direct effect capacity eradicate vitro. We postulate contributes high incidence TPN-associated bacteremia