Meconium aspiration induces ARDS-like pulmonary response in lungs of ten-week-old pigs

摘要: To investigate whether aspiration of meconium induces a hemodynamic and histologic pulmonary response similar to that frequently seen in experimental acute respiratory distress syndrome, twelve 10-week-old pigs with postnatally adapted lungs were studied. Six received 3 ml/kg 20% human via the endotracheal tube. control same age given sterile saline. Ventilator settings adjusted keep PaO2 above 8 kPa PaCO2 below 5 kPa. The consisted two separate hypertensive components. An initial peak artery pressure (PAP) vascular resistance (PVR) was followed by progressive increase PAP PVR group, whereas saline group these parameters returned baseline levels. distribution PVR, determined occlusion, characterized an postarterial immediately after both arterial during later phase. On histological examination, marked neutrophil sequestration lungs. In addition, lung edema formation significantly enhanced as shown increased wet/dry weight ratio. Thus, resulted biphasic pressor severe inflammation. This resembled models syndrome following diverse types precipitating insults; this suggests pathophysiologic mechanisms are elicited cause dysfunction different forms injury.