The role of complement in meconium aspiration syndrome.

摘要: The complement system is part of the host defense with a number biological effects, most which contribute to inflammatory reaction by activation cells like leukocytes and endothelial cells. An intact required for protection against infection maintaining internal homeostasis. However, double-edged sword as improperly or uncontrolled disadvantageous potentially harmful host. Meconium aspiration syndrome (MAS) associated local in lungs, frequently described chemical pneumonitis. Cytokines, arachidonic acid metabolites reactive oxygen species are involved this reaction. We have recently documented that meconium potent activator vitro an experimental piglet model MAS, latter presenting profile closely resembling systemic response syndrome. postulate may pathogenesis MAS.