The TIM gene family regulates autoimmune and allergic diseases

摘要: The recently identified TIM gene family encodes cell-surface receptors that are involved in the regulation of Th1- and Th2-cell-mediated immunity. Tim-3 protein is specifically expressed on Th1 cells negatively regulates responses, whereas Tim-2 preferentially Th2 cells. Tim-1, previously as hepatitis A virus receptor, co-stimulates T-cell expansion cytokine production. Tim-4, which mature dendritic cells, ligand for Tim-1. In mouse models asthma multiple sclerosis, affecting function Tim molecules altered disease phenotype. Because differentially effector further understanding mechanisms by they regulate Th2-effector functions will probably provide opportunities therapeutic modulation immune-mediated diseases.