The TIM gene family: emerging roles in immunity and disease
作者： Vijay K Kuchroo , Dale T Umetsu , Rosemarie H DeKruyff , Gordon J Freeman , None
DOI: 10.1038/NRI1111
关键词:
摘要: The search for cell-surface markers that can distinguish T helper 1 (T(H)1) cells from T(H)2 has led to the identification of a new gene family, encoding T-cell immunoglobulin mucin (TIM) proteins, some which are differentially expressed by T(H)1 and cells. role TIM-family proteins in immune regulation is just beginning emerge. Here, we describe various members mice humans, discuss genetic functional evidence their regulating autoimmune allergic diseases.
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