Influence of the neuronal environment on the pattern of reactive astrocytosis following cerebral ischemia.

摘要: Publisher Summary The specific neuronal environment in which astrocytes are located determines not only their morphology but also many of metabolic properties. influence the on reactive astrocytosis is explored a number animal models, including trauma, demyelination, and toxic-metabolic injury. Several general findings emerged from these studies: astrocytic hypertrophy precedes, more pronounced than astrocyte hyperplasia; increases glial fibrillary acidic protein (GFAP) immunoreactivity necessarily associated with content; can occur seemingly non-damaged brain at sites remote Cerebral ischemia provides unique opportunity to study neuronal-astrocytic interaction injury since global produces necrosis selectively vulnerable areas. Regional differences response, therefore, likely be due throughout cerebral hemispheres experience uniform ischemic insult. chapter presents studies designed determine if early proliferative response indicates increased activity offers possible protection ischemic-induced