Two-stage multi-Gaussian fitting of conduit artery photoplethysmography waveform during induced unilateral hemodynamic events

摘要: Photoplethysmography (PPG) is an optical technique with high diagnostic potential, yet clinical applications remain underdeveloped. Standardization of signal recording and quantification waveform are essential prerequisites for broader use. The aim this study was to utilize a two-stage multi-Gaussian fitting in order examine the parameters conduit artery PPG recorded during increasing unilateral regional vascular resistance (RVR). This conducted on 14 young healthy volunteers; various external compressions (ECs) were performed by inflating tight cuff at 0, 40, 80, 200 mmHg, while registering femoral (wavelength 880 nm), diameter, blood flow linear velocity (vascular ultrasound), arterial pressure (Finapres) states baseline, partial, total occlusion, resultant reactive hyperemia. An increase EC elevated stiffness (AS) distal RVR, caused shift fitted parameters: decreased delay between reflected traverse wave components increased ratio their amplitudes. It concluded that demonstrates approach potentially extending use site assessment diagnostically useful markers e.g., RVR AS.