PIK3CA Mutation in Colorectal Cancer: Relationship with Genetic and Epigenetic Alterations
作者： Katsuhiko Nosho , Takako Kawasaki , Janina A. Longtine , Charles S. Fuchs , Mutsuko Ohnishi
DOI: 10.1593/NEO.08336
关键词: Biology 、 MLH1 、 Population 、 CpG Island Methylator Phenotype 、 Mutation (genetic algorithm) 、 Colorectal cancer 、 Molecular biology 、 DNA methylation 、 CDKN2A 、 Microsatellite instability 、 Cancer research
摘要: … Mutant PIK3CA stimulates the AKT pathway … PIK3CA mutations have been described in 10% to 30% of colorectal cancers [8–15] and have been associated with microsatellite instability (…
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