Conformational study of short peptoid models for future applications as potent antimicrobial compounds

摘要: Development of peptides as clinically useful drugs is limited by their poor metabolic stability and low bioavailability. Recent progresses in chemical synthesis design have led to several strategies for producing potent mimetics. This study aims analyze sequence/structure requirements composition antimicrobial peptoid designs, use peptoids one the most representative approaches meet goal biomimicry. Analysis designs showed that maximum activity minimum hemolysis, plane aromatic residues should be at an angle between 0 90° with respect membranes, cationic need not terminal position, central positions uniform NIle, NLys, NPhe residues.