Investigations of octylglyceryl dextran-graft-poly(lactic acid) nanoparticles for peptide delivery to the brain
作者： Asme Boussahel , Daniel M Ibegbu , Rhita Lamtahri , Julie Maucotel , Julien Chuquet
关键词: Angiotensin II 、 Drug delivery 、 Cytotoxicity 、 Dextran 、 Biochemistry 、 In vivo 、 Lactic acid 、 Peptide 、 Neuropeptide 、 Materials science
摘要: Aim: Develop modified dextran nanoparticles showing potential to assist with drug permeation across the blood–brain barrier for delivery of neuropeptides. Methods: Nanoparticles loaded by emulsification model macromolecular actives were characterized in terms stability, cytotoxicity and drug-release behavior. Peptide-loaded nanoformulations tested an vivo trout food-deprived mice. Results: Nanoformulations peptides showed good stability appeared nontoxic low concentration against human brain endothelial cells. They found preserve bioactivity (angiotensin II) as demonstrated using a model, induce transient reduction food consumption mice when anorexigenic octaneuropeptide. Conclusion: Octylglyceryl dextran-graft-poly(lactic acid) formulated demonstrate peptide delivery.
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