The impact of metabolic and blood pressure control on incidence and progression of nephropathy. A 10-year study of 385 type 2 diabetic patients

摘要: The aim of the present study was to find clinical parameters affecting incidence and progression nephropathy in type 2 diabetic patients. A prospective for 10 years performed 385 patients (diabetes diagnosis > or =30 years) attending a hospital-based outpatient clinic. Medical risk indicators like diabetes duration, HbA(1c), blood pressure were related development nephropathy. 10-year microalbuminuria 38% (n=95) that macroalbuminuria 10% (n=26). Out 103 with microalbuminuria, 38 developed macroalbuminuria. In 252 normoalbuminuric patients, mean HbA(1c) (P<.05) levels obtained during associated doubling fractional albumin clearance. contrast, levels, age, treatment, BMI, gender not (Cox regression analysis). Among 133 micro- macroalbuminuria, 22 more than doubled their serum creatinine level, contrast only 6 without. With Cox analysis, systolic (P<.01), but diastolic, above mentioned factors creatinine. total 19 uremia study, out whom need dialysis 1 has had renal transplantation, 14 (74%) died. (P<.001) uremia, diastolic other above. This shows poor metabolic control is high