Low-protein diet for diabetic nephropathy: a meta-analysis of randomized controlled trials

摘要: Background A low-protein diet (LPD) has been proposed for many years to delay the progression of diabetic nephropathy. However, efficacy an LPD with respect renal outcome is disputed. Objective We aimed determine effect on function in patients type 1 or 2 diseases by using a meta-analysis randomized controlled trials. Design Medline, EMBASE, and Cochrane Central Register Controlled Trials were searched. Eight studies met inclusion criteria our meta-analysis: duration >6 mo, use control group, availability data changes glomerular filtration rate (GFR) creatinine clearance (CCR), albuminuria proteinuria Data combined means fixed-effects model. Weighted mean differences (WMD) calculated change GFR CCR, glycated hemoglobin (HbA(1c)), serum albumin between groups. random-effects model was also used calculate standardized difference urinary excretion proteinuria. Results Overall, WMD CCR not significantly associated LPD, but decrease HbA(1c) significant group (P = 0.005). Although benefit therapy 0.003), great heterogeneity observed. In subgroup analysis, resulted lower concentrations. Conclusion improvement either types