Neurogenic mechanisms and neuropeptides in chronic pain.

摘要: Publisher Summary This chapter focuses on the neurogenic mechanism and neuropeptides in chronic pain. Neuropeptide-mediated cell signalling is complex, its function still unknown. Changes neuropeptide synthesis release are related to pain symptoms that follow inflammation neuropathic injuries. The discusses these specific features of containing afferent neurones describes some properties sensory neurones. also effects neurokinins localized many afferents most extensive studies. substance P exemplify diversity actions have been described for neuropeptides. In spinal dorsal horn, induces changes excitability nerve terminals, neurones, glial cells; events associated with propagation nociceptive signals modulation acute responses. It clear all can be tempered by their chemical environment involve dynamic interactions between (and sympathetic) fibres surrounding tissue. affects neural excitability, but perhaps more significantly over long term, there peptide composition, concentration, release.