Hemozoin as a novel adjuvant for inactivated whole virion influenza vaccine.
作者： Ryuta Uraki , Subash C. Das , Masato Hatta , Maki Kiso , Kiyoko Iwatsuki-Horimoto
DOI: 10.1016/J.VACCINE.2014.07.079
关键词: Virus 、 Hemozoin 、 Adjuvant 、 Vaccination 、 Biology 、 Influenza A virus subtype H5N1 、 Influenza vaccine 、 Virology 、 Immunogenicity 、 Vaccine efficacy
摘要: Because vaccination is an effective means to protect humans from influenza viruses, extensive efforts have been made develop not only new vaccines, but also for adjuvants enhance the efficacy of existing inactivated vaccines. Here, we examined adjuvanticity synthetic hemozoin, a version malarial by-product on vaccine whole viruses in mouse model. We found that mice immunized twice with hemozoin-adjuvanted A/California/04/2009 (H1N1pdm09) or A/Vietnam/1203/2004 (H5N1) virus elicited higher virus-specific antibody responses than did non-adjuvanted counterparts. Furthermore, were better protected lethal challenge Our results show hemozoin improves immunogenicity and thus promising adjuvant virion
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