Ethanol and pentobarbital in combination increase blood-brain barrier permeability to horseradish peroxidase.
作者： P.A. Stewart , E.M. Hayakawa , P.L. Carlen
DOI: 10.1016/0006-8993(88)91593-4
关键词: Horseradish peroxidase 、 Vascular permeability 、 Pharmacology 、 Ketamine hydrochloride 、 Chemistry 、 Calcium in biology 、 Biochemistry 、 Basal lamina 、 Pentobarbital 、 Anesthetic 、 Blood–brain barrier
摘要: The structure and function of the blood-brain barrier (BBB) is determined mainly by characteristics brain capillary endothelial membranes. Lipophilic drugs that modify cell membrane might be anticipated to alter BBB. We investigated effect acute ethanol in combination with either a barbiturate or non-barbiturate anesthetic on ability rat BBB exclude circulating horseradish peroxidase (HRP). Rats were injected into peritoneal cavity plus (pentobarbital) (ketamine hydrochloride) anesthetic. HRP was subsequently transcardially 30 s prior decapitation. In barbiturate-treated rats focal leakage caused levels cerebral cortex about 8-fold higher than ketamine hydrochloride-treated rats. Ultrastructurally cells leaking vascular segments infiltrated and, some cases, they lysed so structural integrity interface lost. Lysed accompanied staining adjacent basal lamina HRP, edematous astrocytic endfeet. These results show causes breakdown structurally damaging cells. Whether damage expansion lysing these two lipophilic drugs, increased intracellular calcium toxic not yet known.
elsevier.com
sci-hub.se 参考文章(40)
R. S. Pozos, S. G. Oakes, The Effects of Ethanol on the Electrophysiology of Calcium Channels Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism. ,vol. 5, pp. 327- 345 ,(1987) , 10.1007/978-1-4899-1684-6_13
P. L. Carlen, N. Gurevich, M. O’Beirne, Electrophysiological Evidence for Increased Calcium-Mediated Potassium Conductance by Low-Dose Sedative-Hypnotic Drugs Springer, Boston, MA. pp. 193- 200 ,(1985) , 10.1007/978-1-4613-2377-8_22
Richard A. Rudick, Stephen J. Buell, Integrity of blood-brain barrier to peroxidase in senescent mice Neurobiology of Aging. ,vol. 4, pp. 283- 287 ,(1983) , 10.1016/0197-4580(83)90004-0
S.C. Phillips, Does ethanol damage the blood--brain barrier? Journal of the Neurological Sciences. ,vol. 50, pp. 81- 87 ,(1981) , 10.1016/0022-510X(81)90043-5
S. C. Phillips, B. G. Cragg, Blood-brain barrier dysfunction in thiamine-deficient, alcohol-treated rats Acta Neuropathologica. ,vol. 62, pp. 235- 241 ,(1984) , 10.1007/BF00691858
T. S. Reese, Morris J. Karnovsky, FINE STRUCTURAL LOCALIZATION OF A BLOOD-BRAIN BARRIER TO EXOGENOUS PEROXIDASE Journal of Cell Biology. ,vol. 34, pp. 207- 217 ,(1967) , 10.1083/JCB.34.1.207
S.C. Phillips, B.G. Cragg, Weakening of the blood-brain barrier by alcohol-related stresses in the rat. Journal of the Neurological Sciences. ,vol. 54, pp. 271- 278 ,(1982) , 10.1016/0022-510X(82)90187-3
B. L. Coomber, P. A. Stewart, Three-dimensional reconstruction of vesicles in endothelium of blood-brain barrier versus highly permeable microvessels. Anatomical Record-advances in Integrative Anatomy and Evolutionary Biology. ,vol. 215, pp. 256- 261 ,(1986) , 10.1002/AR.1092150308
S. W. Leslie, E. Barr, L. J. Chandler, Comparison of voltage-dependent 45Ca2+ uptake rates by synaptosomes isolated from rat brain regions. Journal of Neurochemistry. ,vol. 41, pp. 1602- 1605 ,(1983) , 10.1111/J.1471-4159.1983.TB00870.X
Anil Gulati, Nath Chandishwar, Kirpa Shanker, Rikhab C. Srimal, Keshav N. Dhawan, Krishna P. Bhargava, Effect of alcohols on the permeability of blood-brain barrier. Pharmacological Research Communications. ,vol. 17, pp. 85- 93 ,(1985) , 10.1016/0031-6989(85)90054-2