Alginate-combined cholic acid increased insulin secretion of microencapsulated mouse cloned pancreatic β cells.
作者： Armin Mooranian , Rebecca Negrulj , Ryu Takechi , Emma Jamieson , Grant Morahan
关键词: Cholic acid 、 Bile acid 、 Increased Insulin Secretion 、 Hypoglycemic Effects 、 Internal medicine 、 Insulin 、 Biology 、 Viability assay 、 Endocrinology 、 Inflammation 、 Context (language use)
摘要: Aim: A semisynthetic primary bile acid (PBA) has exerted hypoglycemic effects in Type 1 diabetic animals, which were hypothesized to be due its anti-inflammatory and cellular glucose-regulatory effects. Thus, the research purpose aimed examine antidiabetic of a PBA, terms inflammation survival insulin release, context supporting β-cell delivery treatment. Materials & methods: 10 formulations prepared, five without PBA (control) with (test). Formulations used microencapsulate pancreatic β cells microcapsules examined for morphology, cell viability, release inflammation. Results conclusion: improved reduced formulation-dependent manner, suggests potential use diabetes
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