Using Cocrystals To Systematically Modulate Aqueous Solubility and Melting Behavior of an Anticancer Drug
作者： Christer B. Aakeröy , Safiyyah Forbes , John Desper
DOI: 10.1021/JA907674C
关键词: Solubility 、 Active ingredient 、 Hydrogen bond 、 Molecule 、 Melting point 、 Chemistry 、 Combinatorial chemistry 、 Physical property 、 Organic chemistry 、 Supramolecular chemistry 、 Aqueous solubility
摘要: Five cocrystals of an anticancer compound have been assembled using a well-defined hydrogen-bond-based supramolecular approach that produced the necessary structural consistency in resulting solids. These contain aliphatic even-numbered dicarboxylic acids increasing chain length, and as result, physical properties can be related to molecular structure acid. The melting points five show excellent correlation with individual acids, it has also shown aqueous solubility increased by factor 2.5 relative drug. Consequently, offer range solid forms from which chosen active ingredient where particular property dialed in, provided considerable systematic changes are made participating cocrystallizing agents.
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