Taurine Chloramine: A Possible Oxidant Reservoir
作者： Tetsuya Ogino , Tin Aung Than , Mutsumi Hosako , Michitaka Ozaki , Masako Omori
DOI: 10.1007/978-0-387-75681-3_47
关键词: Ammonia 、 Jurkat cells 、 Cell membrane 、 Cytosol 、 Biophysics 、 Chemistry 、 Respiratory burst 、 Extracellular 、 Hypochlorous acid 、 Taurine
摘要: Taurine is abundant in polymorphonuclear leukocytes (PMNs) where it reacts with PMN-derived hypochlorous acid to form taurine chloramine (Tau-NHCl), a substance that does not readily cross the cell membrane. When PMNs were stimulated PBS lacking taurine, extracellular oxidant concentration was low, but increased 3–4 fold when 15 mM added, indicating lowers levels inside cell. Tau-NHCl added Jurkat cells suspension, its half life about 75 min. In contrast, membrane-permeable ammonia mono-chloramine NH2Cl) has of only 6 Accordingly, NH2Cl oxidizes cytosolic proteins, such as I\upkappaB, and inhibits NF-κB activation, whereas exhibits no comparable effect. However, NH4 + medium, IκB probably through transfer leading formation. These results indicate can serve an reservoir, exhibiting either delayed effects or acting at distant site.
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