Oxygen and Lung Fibrosis
作者： Milos Chvapil , Yei Mei Peng
DOI: 10.1080/00039896.1975.10666770
关键词: Internal medicine 、 Chronic exposure 、 Hydroxyproline 、 Lung tissue 、 Endocrinology 、 Lung 、 Oxygen 、 Lung fibrosis 、 Biochemistry 、 Lactate dehydrogenase 、 Chemistry
摘要: • Young adult rats were continuously exposed to environments containing 9% 10%, 20%, and 80% oxygen for 41 84 days. Animals both extreme concentrations demonstrated a noticeably slowed body growth, the weight of lungs was proportionally lower. The total amount density hydroxyproline in groups markedly higher than an ambient atmosphere. At concentrations, content lactate lung dehydrogenase (LDH) activity higher, as prolyl hydroxylase. finding enhanced peroxidizability lipids (examined by determination malonaldehyde change profile fatty acids) indicates that represent injury constituents. We propose under chronic exposure low (9% 10%) or high (80%) oxygen, tissue damaged (enhanced lipids). It also developed inflamma...
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