Recombinant duck enteritis virus works as a single-dose vaccine in broilers providing rapid protection against H5N1 influenza infection.
作者： Jinxiong Liu , Pucheng Chen , Yongping Jiang , Guohua Deng , Jianzhong Shi
DOI: 10.1016/J.ANTIVIRAL.2012.12.015
关键词: Newcastle disease 、 Virus 、 Duck embryo vaccine 、 Recombinant DNA 、 Inactivated vaccine 、 Virology 、 Influenza A virus subtype H5N1 、 Antibody 、 Biology 、 Vaccination 、 Microbiology
摘要: Abstract Although vaccination is an important strategy for controlling H5N1 avian influenza virus infections, broilers (short-lived meat chickens) remain the major victims in disease-endemic countries. Inactivated vaccine usually requires 2–3 weeks to establish solid protection, and recombinant vaccines, including fowlpox Newcastle disease are affected by maternal antibodies against vectors. These disadvantages compromise protective efficacy of these vaccines broilers. Here, we evaluated safety a new duck enteritis that expresses HA gene (rDEV-re6) specific-pathogen-free chickens We found this rDEV-re6 be safe induce rapid protection after single dose. This may therefore serve as ideal single-dose
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