A label-free aptasensor for carcinoembryonic antigen detection using three-way junction structure and ATMND as a fluorescent probe
作者： Noor Mohammad Danesh , Rezvan Yazdian-Robati , Mohammad Ramezani , Mona Alibolandi , Khalil Abnous
DOI: 10.1016/J.SNB.2017.10.126
关键词: Molecular biology 、 Carcinoembryonic antigen 、 Fluorescence intensity 、 Aptamer 、 Three way 、 Label free 、 Chemistry 、 Chromatography 、 Detection limit 、 Fluorescence
摘要: Herein, we report a novel approach to design a fluorescent aptasensor for detection of carcinoembryonic antigen (CEA), a tumor marker, using three-way junction pocket and 5, 6, 7-trimethyl-1, 8-naphthyridin-2-amine (ATMND) as a fluorescent agent. The analytical method was based on the entrapment of ATMND in the three-way junction pocket in the absence of CEA, leading to a significant decrease of fluorescence intensity of ATMND. Under, the optimum condition, the relative fluorescence intensity indicated a wide linearity …
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