Immunoregulation in glomerulonephritis, Henoch--Schonlein purpura and lupus nephritis.
作者： K M Bannister , A R Clarkson , P A Drew , A J Woodroffe
DOI:
关键词: Pokeweed mitogen 、 Immune system 、 Lupus nephritis 、 T cell 、 Endocrinology 、 Membranous nephropathy 、 Biology 、 Glomerulonephritis 、 Antibody 、 Immunology 、 Henoch-Schonlein purpura 、 Internal medicine
摘要: Immunoregulation was examined in normal controls and patients with immune complex glomerulonephritis lupus nephritis (SLE) using OKT monoclonal anti-bodies against helper (OKT4) suppressor (OKT8) T cell subsets. Functional studies assessed control of vitro immunoglobulin synthesis by cultured peripheral blood mononuclear cells (PBMC). IgG IgA measured unstimulated, pokeweed mitogen (PWM) stimulated PWM + concanavalin A (Con A) cultures. Patients primary membranous nephropathy (MN) mesangial (IgA GN) were found to have elevated T4/T8 ratios secondary a deficiency the T8+ subset. SLE had low ratios. B activation high spontaneous present cultures from SLE, GN Henoch-Schonlein purpura (HSP). Defective Con inducible suppression HSP lesser extent, MN. defects correlated only All four disorders appear share disturbances cellular response various degrees defective suppression; however, it is not clear these whether are or phenomena.
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