Tolerability and Kinetics of a Solvent-Detergent-Treated Intravenous Immunoglobulin Preparation in Hypogammaglobulinaemia Patients
作者： Freja Ebeling , Maija Baer , Pirkko Hormila , Greta Järventie , Pirjo Koistinen
DOI: 10.1111/J.1423-0410.1995.TB01675.X
关键词: Kinetics 、 Blood product 、 Gastroenterology 、 Solvent detergent 、 Tolerability 、 Internal medicine 、 Antibody 、 Anesthesia 、 Pharmacokinetics 、 Adverse effect 、 Medicine 、 Immunoglobulin E 、 Hematology 、 General Medicine
摘要: The tolerability and kinetics of a solvent-detergent-treated 6% intravenous immunoglobulin (IVIG) preparation were studied in 15 hypogammaglobulinaemia patients during 3-4 regular substitution infusions 9-48 g, the mean dose being 359 mg/kg. well tolerated, trough serum IgG levels achieved comparable to two commercial IVIG preparations. stepwise increase infusion rate up 5 mg/kg/min use this as 12% solution possible without serious adverse events all 6 patients. This greatly reduced time needed for infusions.
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