Arteriolosclerotic leucoencephalopathy in the elderly and its relation to white matter lesions in Binswanger's disease, multi-infarct encephalopathy and Alzheimer's disease

摘要: Arteriolosclerotic leucoencephalopathy in the elderly (ALE) is characterized by white matter lesions associated with atherosclerosis and arteriolosclerosis. Mild are focal probably represent early status cribosus or incomplete lacunar infarcts. Moderate severe diffuse areas of demyelination centrum semiovale which infarcts seldom observed. The incidence ALE a consecutive necropsy series 50 cases (mean age 62.6 +/- 13.1 years) was 52%, it rare fourth fifth decades but increased thereafter to reach prevalence 100% at 80 years. occurred 19 patients were moderate 7 (14%). mean higher this group (74.7 7.6 than changes as whole. Dementia only 3 ALE. These data suggest that (a) common old cause leuko-araiosis most CT scans elderly; (b) may be asymptomatic; (c) severity not related neurological deficits; (d) multiple degenerative diseases (i.e., Alzheimer's disease) main dementia White ALE, Binswanger's disease, transition multi-infarct encephalopathy (MIE) disease (AD) similar morphology result subacute hypoperfusion/hypoxic process. Increased arterial blood pressure frequent risk factor MIE, whereas congophilic angiopathy meningeal cortical vessels, addition mild arteriolar hyalinosis matter, play role pathogenesis infarctation AD.