Drugging Topoisomerases: Lessons and Challenges
作者： Yves Pommier
DOI: 10.1021/CB300648V
关键词: Biochemistry 、 Genetics 、 Topoisomerase inhibitor 、 Gene 、 DNA 、 DNA supercoil 、 Enzyme 、 Mechanism of action 、 Topoisomerase 、 Biology 、 Transcription (biology)
摘要: Topoisomerases are ubiquitous enzymes that control DNA supercoiling and entanglements. They are essential during transcription and replication, and topoisomerase inhibitors are …
acs.org
sci-hub.se 参考文章(142)
Yves Pommier, Juana M. Barcelo, V. Ashutosh Rao, Olivier Sordet, Andrew G. Jobson, Laurent Thibaut, Ze‐Hong Miao, Jennifer A. Seiler, Hongliang Zhang, Christophe Marchand, Keli Agama, John L. Nitiss, Christophe Redon, Repair of topoisomerase I-mediated DNA damage. Progress in Nucleic Acid Research and Molecular Biology. ,vol. 81, pp. 179- 229 ,(2006) , 10.1016/S0079-6603(06)81005-6
Y H Hsiang, R Hertzberg, S Hecht, L F Liu, Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. Journal of Biological Chemistry. ,vol. 260, pp. 14873- 14878 ,(1985) , 10.1016/S0021-9258(17)38654-4
Yves Pommier, Christine Jaxel, Kurt W. Kohn, Joseph M. Covey, Protein-linked DNA strand breaks induced in mammalian cells by camptothecin, an inhibitor of topoisomerase I. Cancer Research. ,vol. 49, pp. 5016- 5022 ,(1989)
C. Jaxel, G. Capranico, D. Kerrigan, K.W. Kohn, Y. Pommier, Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin. Journal of Biological Chemistry. ,vol. 266, pp. 20418- 20423 ,(1991) , 10.1016/S0021-9258(18)54939-5
John M. Fortune, Neil Osheroff, Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice. Progress in Nucleic Acid Research and Molecular Biology. ,vol. 64, pp. 221- 253 ,(2000) , 10.1016/S0079-6603(00)64006-0
Yves Pommier, Kurt W. Kohn, Ann Orr, Jean-François Riou, Differential effects of amsacrine and epipodophyllotoxins on topoisomerase II cleavage in the human c-myc protooncogene. Cancer Research. ,vol. 52, pp. 3125- 3130 ,(1992)
Franco Zunino, Antonella Riva, Stella Tinelli, Giovanni Capranico, Teresa Dasdia, Markedly Reduced Levels of Anthracycline-induced DNA Strand Breaks in Resistant P388 Leukemia Cells and Isolated Nuclei Cancer Research. ,vol. 47, pp. 3752- 3756 ,(1987)
L A Zwelling, D Kerrigan, Y Pommier, S Michaels, A Steren, K W Kohn, Formation and resealing of intercalator-induced DNA strand breaks in permeabilized L1210 cells without the stimulated synthesis of poly(ADP-ribose). Journal of Biological Chemistry. ,vol. 257, pp. 8957- 8963 ,(1982) , 10.1016/S0021-9258(18)34226-1
Kurt W. Kohn, Beyond DNA Cross-Linking: History and Prospects of DNA-targeted Cancer Treatment--Fifteenth Bruce F. Cain Memorial Award Lecture Cancer Research. ,vol. 56, pp. 5533- 5546 ,(1996)
Tito Fojo, Yves Pommier, Chris Takimoto, Susan E. Bates, Glenda Kohlhagen, Mariafiorella Brangi, Robert Robey, Thomas Litman, Kenryu Nishiyama, Marco Ciotti, Camptothecin resistance: role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells. Cancer Research. ,vol. 59, pp. 5938- 5946 ,(1999)