Significant association of SREBP-2 genetic polymorphisms with avascular necrosis in the Korean population.
作者： Tae-Ho Kim , Jeong-In Baek , Jung Min Hong , Su-Jin Choi , Hye-Jin Lee
关键词: Bone disease 、 Haplotype 、 Avascular necrosis 、 Genetics 、 Single-nucleotide polymorphism 、 Linkage disequilibrium 、 Bioinformatics 、 Allele frequency 、 Cholesterol 、 Biology 、 Femoral head
摘要: Background It is known that steroid usage and alcohol abuse are major etiological factors in the development of avascular necrosis (AVN), a bone disease produces osteonecrosis femoral head. The facilitation fat biosynthesis by steroids disrupts blood supply into SREBP-2 plays central role maintenance lipid homeostasis through stimulating expression genes associated with cholesterol biosynthetic pathways. aim this study was to examine association between polymorphisms gene AVN susceptibility Korean population.
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