Genome sequence of Babesia bovis and comparative analysis of apicomplexan hemoprotozoa.

摘要: Babesia bovis is an apicomplexan tick-transmitted pathogen of cattle imposing a global risk and severe constraints to livestock health economic development. The complete genome sequence was undertaken facilitate vaccine antigen discovery, allow for comparative analysis with the related hemoprotozoa Theileria parva Plasmodium falciparum. At 8.2 Mbp, B. similar in size that spp. Structural features T. genomes are remarkably similar, extensive synteny present despite several chromosomal rearrangements. In contrast, P. falciparum, which have clinical pathological features, major differences size, chromosome number, gene complement. Chromosomal falciparum limited microregions. has allowed wide scale analyses polymorphic variant erythrocyte surface protein (ves1 gene) family that, var genes, postulated play role cytoadhesion, sequestration, immune evasion. ∼150 ves1 genes found clusters distributed throughout each chromosome, increased concentration adjacent physical gap on 1 contains multiple ves1-like sequences. frequently linked novel termed smorfs may themselves contribute evasion, biology, or both. Initial expression smorf indicates coincident transcription variants. displays metabolic potential, numerous missing pathways, including two pathways previously described apicoplast. This reduced potential reflected apicoplast, appears fewer nuclear targeted it than other apicoplast containing organisms. Finally, identified candidates positional homolog p67 SPAG-1, sporozoite antigens provides greater understanding metabolism avenues drug therapies