Anti-Proliferative Activity of Meroditerpenoids Isolated from the Brown Alga Stypopodium flabelliforme against Several Cancer Cell Lines
作者： David M. Pereira , Jose Cheel , Carlos Areche , Aurelio San-Martin , Juana Rovirosa
DOI: 10.3390/MD9050852
关键词: Antimicrobial 、 Cell culture 、 Bacillus cereus 、 Cell growth 、 Microbiology 、 Chinese hamster 、 Enterococcus faecalis 、 Proteus mirabilis 、 Micrococcus luteus 、 Biology
摘要: The sea constitutes one of the most promising sources novel compounds with potential application in human therapeutics. In particular, algae have proved to be an interesting source new bioactive compounds. this work, six meroditerpenoids (epitaondiol, epitaondiol diacetate, monoacetate, stypotriol triacetate, 14-ketostypodiol diacetate and stypodiol) isolated from brown alga Stypopodium flabelliforme were tested for their cell proliferation inhibitory activity five lines. Cell lines included colon adenocarcinoma (Caco-2), neuroblastoma (SH-SY5Y), rat basophilic leukemia (RBL-2H3), murine macrophages (RAW.267) Chinese hamster fibroblasts (V79). Antimicrobial was also evaluated against Staphylococcus aureus, Salmonella typhimurium, Proteus mirabilis, Bacillus cereus, Enterococcus faecalis Micrococcus luteus. Overall, showed good all lines, SH-SY5Y RAW.267 being susceptible. capacity observed triacetate stypodiol, first active. results suggest that these molecules deserve further studies order evaluate as therapeutic agents.
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