The Molecular Mechanism Underlying Continuous Exercise Training-Induced Adaptive Changes of Lipolysis in White Adipose Cells

作者: Junetsu Ogasawara , Tetsuya Izawa , Tomonobu Sakurai , Takuya Sakurai , Ken Shirato

DOI: 10.1155/2015/473430

关键词: Regulation of gene expressionMetabolismLipolysisAdipose tissueAdipose triglyceride lipasePhosphorylationDownregulation and upregulationBiologyLipaseInternal medicineEndocrinology

摘要: Physical exercise accelerates the mobilization of free fatty acids from white adipocytes to provide fuel for energy. This happens in several tissues and helps regulate a whole-body state metabolism. Under these conditions, hydrolysis triacylglycerol (TG) that is found known be augmented via activation lipolytic events, which referred as “lipolytic cascade.” Indeed, evidence has shown responses are upregulated by continuous training (ET) through adaptive changes molecules constitute cascade. During past few decades, many lipolysis-related have been identified. Of note, discovery new lipase, adipose triglyceride redefined existing concepts hormone-sensitive lipase-dependent TG adipocytes. review outlines alterations result ET, includes molecular regulation lipases

参考文章(77)
Li-Jyun Syu, Alan R Saltiel, Lipotransin: a novel docking protein for hormone-sensitive lipase. Molecular Cell. ,vol. 4, pp. 109- 115 ,(1999) , 10.1016/S1097-2765(00)80192-6
R C Honnor, G S Dhillon, C Londos, cAMP-dependent protein kinase and lipolysis in rat adipocytes. I. Cell preparation, manipulation, and predictability in behavior. Journal of Biological Chemistry. ,vol. 260, pp. 15122- 15129 ,(1985) , 10.1016/S0021-9258(18)95711-X
A.S. Greenberg, J.J. Egan, S.A. Wek, N.B. Garty, E.J. Blanchette-Mackie, C. Londos, Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets. Journal of Biological Chemistry. ,vol. 266, pp. 11341- 11346 ,(1991) , 10.1016/S0021-9258(18)99168-4
Peter Vermathen, Pierre Saillen, Andreas Boss, Monica Zehnder, Chris Boesch, Skeletal muscle 1H MRSI before and after prolonged exercise. I. muscle specific depletion of intramyocellular lipids Magnetic Resonance in Medicine. ,vol. 68, pp. 1357- 1367 ,(2012) , 10.1002/MRM.24168
M Lafontan, M Berlan, Fat cell adrenergic receptors and the control of white and brown fat cell function Journal of Lipid Research. ,vol. 34, pp. 1057- 1091 ,(1993) , 10.1016/S0022-2275(20)37695-1
B. M. Popkin, M. M. Slining, New dynamics in global obesity facing low- and middle-income countries Obesity Reviews. ,vol. 14, pp. 11- 20 ,(2013) , 10.1111/OBR.12102
Christopher M. Jenkins, David J. Mancuso, Wei Yan, Harold F. Sims, Beverly Gibson, Richard W. Gross, Identification, Cloning, Expression, and Purification of Three Novel Human Calcium-independent Phospholipase A2Family Members Possessing Triacylglycerol Lipase and Acylglycerol Transacylase Activities Journal of Biological Chemistry. ,vol. 279, pp. 48968- 48975 ,(2004) , 10.1074/JBC.M407841200
Hideaki Miyoshi, James W. Perfield, Sandra C. Souza, Wen-Jun Shen, Hui-Hong Zhang, Zlatina S. Stancheva, Fredric B. Kraemer, Martin S. Obin, Andrew S. Greenberg, Control of Adipose Triglyceride Lipase Action by Serine 517 of Perilipin A Globally Regulates Protein Kinase A-stimulated Lipolysis in Adipocytes Journal of Biological Chemistry. ,vol. 282, pp. 996- 1002 ,(2007) , 10.1074/JBC.M605770200