Neonatal desipramine or zimeldine treatment causes long-lasting changes in brain monoaminergic systems and alcohol related behavior in rats.
作者： L.A. Hilakivi , D. Stenberg , J.D. Sinclair , K. Kiianmaa
DOI: 10.1007/BF00216004
关键词: Desipramine 、 Dopamine 、 Sleep in non-human animals 、 Monoamine neurotransmitter 、 Endocrinology 、 Monoaminergic 、 Defecation 、 Antidepressant 、 Internal medicine 、 Open field 、 Medicine
摘要: To study the relationship between neonatal antidepressant administration, active (REM) sleep and adult alcohol-related behavior, rat pups were treated daily with 5 mg/kg despramine (DMI) or 25 zimeldine SC from 6th to 19th postnatal days. Movement sensitive mattress (“SCSB”) measurements showed that treatment suppressed throughout whole period, but DMI was more effective during first 8 days than last At age of 70 days, zimeldine-treated rats expressed a selective increase some components activity in open field test, had higher defecation score compared controls. Furthermore, zimeldine-rats responded decrease ambulation an alcohol dose which generally stimulates locomotion rats. 3 months increased voluntary intake 10% (v/v) alcohol. Measurement brain monoamines revealed interfered normal development function monoamine neuronal systems: concentrations noradrenaline, dopamine 5-hydroxytryptamine (5-HT), their metabolites altered several regions. The results thus suggest suppresses has influence on later possibly due long-lasting defect monoaminergic transmission.
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