Activation of murine macrophage cell line RAW 264.7 by Korean propolis.

摘要: Monocytes and macrophages play a major role in defense mechanism of the host response to tumor, part through secretion several potent products macrophage cytokines. tissue produce at least two groups protein mediators inflammation, interleukin 1 (IL-1) tumor necrosis factor (TIMF). Recent studies emphasizes that TNF IL-1 modulate inflammatory function endothelial cells, leukocytes, fibroblasts. In this study, our work is directed toward studying thein vitro effects Korean propolis on ability induce cellular secretory responses murine cell line, RAW 264.7. It was found Water Extract Propolis (WEP) could activate by producing The production cytokines, TNF-α, 264.7 treated with WEP examined from 2.5 μg/ml up 25 dose dependent manner. Nitric oxide (NO) also increased when cells were exposed combination LPS μg/ml. At high (50 100 μg/ml) used prescribe for anti-inflammatory analgesic medicine showed inhibition NO LPS-stimulated macrophage. Besides cytokine production, release, surface molecule expression morphologic antigen stimulation WEP. These results suggested may activation.