Neonatal cocaine exposure, activity, and responsivity to cocaine in a rodent model

摘要: This study examined the effects of neonatal cocaine exposure on running wheel activity and subsequent responsivity to using a rodent model. Subjects were artificially reared from postnatal (PND) days 4-10 via an intragastric cannula. The four treatment groups included two doses (20 mg/kg/day 40 mg/kg/day), control normally suckled control. tested at either PND 21 through 24 (Experiment 1) or 60 70 2) for 2 consecutive days. Testing consisted 30-min habituation period followed by injection saline (Day additional 60-min test session. Neonatal had little effect baseline following age. All subjects showed activation with injections, however, was more pronounced in juveniles. Again, did not interact response cocaine. These findings suggest that does alter long-term 20 mg/kg as measured apparatus.