Body weight gain and hippocampal volumes of rats exposed neonatally to psychostimulants

摘要: Abstract There is increasing evidence that early exposure to psychostimulants exerts long-lasting effects on the central nervous system. Yet, analysis of body weight gain and volumetric determinations brain areas have not beenperformed by comparing neonatal cocaine amphetamine. Male (Wistar) rats were given hydrochloride (15 mg/kg weight/day), d -amphetamine sulphate (25 weight/day) or saline, s.c., twice daily, from postnatal day (PND) 1 30. The experimental design used random permuted blocks 4 males per litter - 9 litters for evolution body, cerebellum at PND30. Volumes hippocampal formation calculated in horizontal serial sections celloidin embedded material 6 animals group. was performed using discriminant functions allowed separation amphetamine group remainder control group; PND 24–30 period presented highest discriminating power. mean volume lower group, differences significant molecular layer dentate gyrus exposed when compared with controls. functional repercussions allied decreased after psychostimulant are likely be noteworthy since, whether permanent simply representing a developmental delay, they will induce reduction input information towards hippocampus which may relevant behavioral described psychostimulants, during active development.