Stimulation of brain metabolism by perinatal cocaine exposure.

作者: Diana L. Dow-Edwards , Laurél A. Freed , Thomas H. Milhorat

DOI: 10.1016/0165-3806(88)90209-X

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摘要: Cocaine was administered to neonatal rats between day 1 and 10, which in the rat falls within a developmental stage roughly equivalent third trimester of gestation human fetuses. At 60 days age, when animals had reached adulthood, cerebral glucose metabolic patterns were examined by quantitative autoradiography. Adult females, but not adult males, exhibited significant increases activity number structures, including those limbic, motor, sensory systems. Many these structures are same as excited acute administration cocaine other stimulants. These data suggest that consumption during pregnancy may constitute risk factor leading long-term alterations brain function adult.

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