Lesions in respiratory bronchioles and conducting airways of monkeys exposed to ambient levels of ozone

摘要: Abstract Bonnet monkeys were exposed for 7 days, 8 hr/day to 0.2 and 0.35 ppm ozone. Ozone at is commonly encountered by man in urban areas. Two anatomically related gradients of airway damage present the monkeys. The first most severe gradient was proximal generations respiratory bronchioles resulted mild hyperplasia nonciliated cuboidal epithelial cells intraluminal accumulation alveolar macrophages. Squamous bronchiolar type 1 alveoli reduced number occasionally had swollen cytoplasm. A second ozone-induced less consistently produced tracheas bronchi. Clusters longitudinal tracts ciliated these airways markedly shortened cilia. Numerous microvilli-covered area with short cilia interpreted as being regenerating cells. results this study demonstrate that lesions are primates short-term exposure ozone concentrations focus consistent damage.